Английская Википедия:DEFA4

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Версия от 20:20, 23 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Defensin, alpha 4''' ('''DEFA4'''), also known as '''neutrophil defensin 4''' or '''HNP4''', is a human defensin peptide that is encoded by the ''DEFA4'' gene.<ref name="entrez">{{Cite web| title = Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (''Homo sapiens'') | url = https:...»)
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Шаблон:Short description Шаблон:Infobox gene

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[1][2] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[3] and viruses.[4]

Function

Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[5] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[1]

References

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Further reading

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Шаблон:Gene-8-stub