Английская Википедия:DEFB106A

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Версия от 20:20, 23 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Beta-defensin 106''' is a protein that in humans is encoded by the ''DEFB106A'' gene.<ref name="pmid11854508">{{cite journal | vauthors = Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, ((McCray PB Jr)) | title = Discovery of five conserved beta -defensin gene clusters using a...»)
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Шаблон:Short description Шаблон:Infobox gene Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.[1][2]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.[2]

Function

The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.[3]

References

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Further reading

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