Английская Википедия:DUSP5

Материал из Онлайн справочника
Версия от 22:46, 23 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Dual specificity protein phosphatase 5''' is an enzyme that in humans is encoded by the ''DUSP5'' gene.<ref name="pmid7806236">{{cite journal | vauthors = Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM | title = Chromosomal localization of four human VH1-like protein-tyrosine phosphatase...»)
(разн.) ← Предыдущая версия | Текущая версия (разн.) | Следующая версия → (разн.)
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:Infobox gene Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.[1][2]

Function

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1/2, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.[2]

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

Шаблон:PDB Gallery

Шаблон:Protein tyrosine phosphatases


Шаблон:Gene-10-stub

Партнерские ресурсы
Криптовалюты
Магазины
Хостинг
Разное

  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite web
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:DUSP5&oldid=14152764