Английская Википедия:Docosatetraenoic acid
Материал из Онлайн справочника
Docosatetraenoic acid designates any straight chain 22:4 fatty acid. (See essential fatty acid for nomenclature.)
One isomer is of particular interest:
- all-cis-7,10,13,16-docosatetraenoic acid is an ω-6 fatty acid with the common name adrenic acid (AdA). This is a naturally occurring polyunsaturated fatty acid formed through a 2-carbon chain elongation of arachidonic acid. It is one of the most abundant fatty acids in the early human brain.[1] This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins,[2] and epoxydocosatrienoic acids (EDTs, also known as dihomo-EETs).[3] [4] [5] In addition to being endothelium-derived hyperpolarizing factors, EDTs have demonstrated anti-endoplasmic reticulum stress and anti-nociceptive activities. They are hydrolyzed by the soluble epoxide hydrolase (sEH) to dihydroxydocosatrienoic acids (DHDTs) and hence might play a role in the efficacy of sEH inhibitors.
See also
References
Further reading
- Ferretti, A., Flanagan, V.P. Mass spectrometric evidence for the conversion of exogenous adrenate to dihomo-prostaglandins by seminal vesicle cyclo-oxygenase. A comparative study of two animal species. J Chromatogr 383 241-250 (1986).
- Sprecher, H., VanRollins, M., Sun, F., et al. Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. J Biol Chem 257 3912-3918 (1982).
