Английская Википедия:Doege–Potter syndrome
Шаблон:Distinguish Шаблон:Infobox medical condition (new)
Doege–Potter syndrome (DPS) is a paraneoplastic syndrome[1] in which hypoglycemia is associated with solitary fibrous tumors. The hypoglycemia is the result of the tumors producing insulin-like growth factor 2.[2] The syndrome was first described in 1930, by Karl Walter Doege (1867–1932), a German-American physician[3] and by Roy Pilling Potter (1879–1968), an American radiologist, working independently;[4] the full term Doege–Potter syndrome was infrequently used until the publication of a 2000 article[5] using the eponym.[6]
DPS is rare (as of 1976, less than one hundred cases were described[7]), with a malignancy rate of 12–15%. Actual rates of hypoglycemia associated with a fibrous tumor are quite rare (a 1981 study of 360 solitary fibrous tumors of the lungs found that only 4% caused hypoglycemia[8]), and are linked to large tumors with high rates of mitosis.[9] Removal of the tumor will normally resolve the symptoms.[1][9]
Tumors causing DPS tend to be quite large;[10] in one case a Шаблон:Convert, Шаблон:Convert mass was removed, sufficiently large to cause a collapsed lung.[5] In X-rays, they appear as a single mass with visible, defined borders, appearing at the edges of the lungs or a fissure dividing the lobes of the lungs.[10] Similar hypoglycemic effects have been related to mesenchymal tumors.[6]
References
Шаблон:Paraneoplastic syndromes
Шаблон:Endocrine gland neoplasia
