Английская Википедия:Dolichol kinase

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Версия от 06:50, 28 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{infobox enzyme | Name = dolichol kinase | EC_number = 2.7.1.108 | CAS_number = 71768-07-5 | GO_code = 0004168 | image = | width = | caption = }} {{Infobox_gene}} In enzymology, a '''dolichol kinase''' ({{EC number|2.7.1.108}}) is an enzyme that...»)
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Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox enzyme Шаблон:Infobox gene

In enzymology, a dolichol kinase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

CTP + dolichol <math>\rightleftharpoons</math> CDP + dolichyl phosphate

Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in N-glycan biosynthesis.

In humans dolichol kinase is encoded by the DOLK gene.[1][2][3]

Function

Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER). Dolichol kinase catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate biosynthesis.[4]

Clinical significance

Mutations in DOLK cause a subtype of the congenital disorders of glycosylation, DOLK-CDG (CDG-Im).[5]

See also

References

Шаблон:Reflist

Further reading

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Шаблон:Refend

External links

Шаблон:Glycoprotein metabolism enzymes Шаблон:Kinases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:2.7-enzyme-stub Шаблон:Gene-9-stub

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  1. ↑ Шаблон:Cite journal
  2. ↑ Шаблон:Cite journal
  3. ↑ Шаблон:Cite web
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:Dolichol_kinase&oldid=14343313