Английская Википедия:E. Sally Ward
Шаблон:Short description Шаблон:For Шаблон:Infobox scientist Elizabeth Sally Ward Шаблон:Post-nominals is a British physician who is Director of Translational Immunology at the Centre for Cancer Immunology in the University of Southampton.[1][2] She was elected Fellow of the Royal Society in 2022.[3]
Early life and education
Ward was an undergraduate student at the University of Cambridge, where she studied the Natural Sciences Tripos with a focus on biochemistry. She remained at Cambridge for her doctoral research, working under the supervision of David J. Ellar at Gonville and Caius College, Cambridge.[4][5][6] Her PhD research investigated the genetics of delta endotoxin from Bacillus thuringiensis israelensis.[7]
Research and career
Ward remained at Cambridge as a junior research fellow, working in both Gonville and Caius College and Sidney Sussex College, Cambridge.[8]
In 1990, Ward moved to the United States. She joined the University of Texas Southwestern Medical Center, where she was a member of the founding team of the Centre for Immunology. She was awarded various named chairs in Texas, including the Paul and Betty Meek-FINA Professorship. In 1996, Ward identified the Fc receptor, a regulator of Immunoglobulin G levels.[9] She moved to the Texas A&M University Health Sciences University in 2014.[9] In 2018, Ward returned to the United Kingdom, joining the University of Southampton as Professor of Molecular Immunology and Director of Translational Immunology.[10][11]
Ward works on antibody and protein engineering to treat autoimmune disease.[12] She makes use of in vivo studies to design novel anti-body therapies for the treatment of cancer. Her early identification of the Fc receptor has resulted in the development of FcRn antagonist technologies.[13][14] Ward has licensed these Abdegs (antibodies that enhance IgG degradation) to the pharmaceutical industry, resulting in anti-body therapeutics.[9][14][15]
Ward has developed advanced microscopies and image analysis techniques. She has demonstrated single molecule spectroscopy is capable of imaging single protein molecules at exceptional resolution. She uses multi-colour imaging to interrogate the cell surfaces. Using these approaches, Ward visualised the biological pathways intracellular endoscopes to the plasma membrane (and vice versa).[12] She has also pioneered open access software packages for miroscopy analysis.[12]
Awards and honours
- 2018 Royal Society Wolfson Research Merit AwardШаблон:Citation needed
- 2020 Elected Vice President of the Antibody Society[9]
- 2022 Elected Fellow of the Royal Society[3]
Selected publications
- Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli[16]
- Localization accuracy in single-molecule microscopy"[17]
- Multiple roles for the major histocompatibility complex class I- related receptor FcRn[18]
- Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies[19]
References
- ↑ Шаблон:Google scholar id
- ↑ Шаблон:EuropePMC
- ↑ 3,0 3,1 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite q
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite thesis
- ↑ Шаблон:Cite web
- ↑ 9,0 9,1 9,2 9,3 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ 12,0 12,1 12,2 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ 14,0 14,1 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite Q
- ↑ Шаблон:Cite Q
- ↑ Шаблон:Cite Q
- ↑ Шаблон:Cite q
- Английская Википедия
- Living people
- British biochemists
- Fellows of the Royal Society
- Alumni of Gonville and Caius College, Cambridge
- Academics of the University of Southampton
- Royal Society Wolfson Research Merit Award holders
- 20th-century British scientists
- Year of birth missing (living people)
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