Английская Википедия:Edotreotide

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Шаблон:Chembox Шаблон:Infobox drug

Edotreotide (USAN, also known as (DOTA0-Phe1-Tyr3) octreotide, DOTA-TOC, DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer.[1] When used therapeutically it is an example of peptide receptor radionuclide therapy.

Yttrium-90

A phase I clinical trial of yttrium-90 labelled edotreotide concluded in 2011,[2] aiming to investigated effects in young cancer patients (up to 25 years of age). Specific cancers being included in the trial include neuroblastoma, childhood brain tumours and gastrointestinal cancer.[3]

A phase II trial for the use of 90Y DOTA-TOC for patients with metastatic carcinoid, where octreotide treatment was no longer effective, also reported results in 2010.[4]

Файл:Yttrium-90 edotreotide.svg
Yttrium-90 labeled edotreotide
Шаблон:Clear left

Lutetium-177

Lutetium-177 labelled edotreotide (177Lu-DOTA-TOC), with the trade name Solucin, is the subject of a phase 3 clinical trial for treatment of GEP-NETs.[5][6] It was granted orphan drug designation by the European Medicines Agency in 2014.[7]

See also

References

Шаблон:Reflist

External links

Шаблон:GH/IGF-1 axis signaling modulators Шаблон:Portal bar


Шаблон:Pharma-stub

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  1. ↑ Martindale, The Extra Pharmacopoeia, 30th ed, p1161.
  2. ↑ Шаблон:Cite journal
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite web
  6. ↑ Шаблон:Cite web
  7. ↑ Шаблон:Cite web
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:Edotreotide&oldid=14457042