Английская Википедия:Enolase 2
Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[1][2] Gamma-enolase is a phosphopyruvate hydratase.
Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[1]
Interactive pathway map
Шаблон:GlycolysisGluconeogenesis WP534
Utility
Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.[3]
References
Further reading
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External links
Шаблон:PDB Gallery Шаблон:Carbon-oxygen lyases Шаблон:Enzymes Шаблон:Portal bar Шаблон:Tumor markers