Английская Википедия:Enoyl-acyl carrier protein reductase
Шаблон:Short description Шаблон:Infobox enzyme Enoyl-acyl carrier protein reductase (or ENR) (Шаблон:EC number), is a key enzyme of the type II fatty acid synthesis (FAS) system.[1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.[2]
At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.[3]
See also
- Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
- Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
- Cis-2-enoyl-CoA reductase (NADPH)
References
External links
Шаблон:Lipid metabolism enzymes Шаблон:CH-CH oxidoreductases Шаблон:Enzymes Шаблон:Portal bar
