Английская Википедия:Enramycin
Шаблон:Short description Шаблон:Drugbox
Enramycin (also knownb as enduracidin) is a polypeptide antibiotic produced by Streptomyces fungicidus. Enramycin is widely used as a feed additive for pigs and chickens to prevent necrotic enteritis induced by Gram-positive gut pathogens.[1]
Mechanism of action
Enramycin acts as an inhibitor of the enzyme MurG, which is essential for cell wall biosynthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibiting this step greatly compromises cell wall integrity leading to cell lysis.[2]
Spectrum of susceptibility
Enramycin has been found to be very effective against Gram-positive gut pathogens, most notably, Clostridium perfringens; a leading cause of necrotic enteritis.Шаблон:Citation needed The following represents MIC data for a couple of veterinary pathogens.[3]
- Clostridium perfringens: 0.05 μg/ml – 1.6 μg/ml
- Staphylococcus aureus: 0.013 μg/ml – 0.413 μg/ml
Composition
Standard grade enramycin is composed of two main components called enramycin A and enramycin B. These two components are routinely used as analytical reference standards; however, their activity as individual compounds does not appear to be widely studied or characterized.[4]
References
- ↑ Schering-Plough. "Enramycin." Darou Gostar Group. N.p., n.d. Web. 13 Mar. 2014.
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
