Английская Википедия:Estriol sulfamate
Шаблон:Short description Шаблон:Drugbox
Estriol sulfamate (developmental code name J1034), or estriol 3-O-sulfamate, is a synthetic estrogen and estrogen ester which was never marketed.[1][2][3] It is the C3 sulfamate ester of estriol.[1][2] The drug shows substantially improved oral estrogenic potency (vagina, uterus) relative to estriol in rats but without an increase in hepatic estrogenic potency.[1] However, the closely related compound estradiol sulfamate (E2MATE) failed to show estrogenic activity in humans, which is due to the fact that it is additionally a highly potent inhibitor of steroid sulfatase which regulates the estrogenicity of such compounds[4] and thus it prevents its own bioactivation into estradiol.[5]
See also
References
Шаблон:Estrogen receptor modulators
Шаблон:Steroid-stub
Шаблон:Genito-urinary-drug-stub
- ↑ 1,0 1,1 1,2 Шаблон:Cite journal
- ↑ 2,0 2,1 Шаблон:Cite journal
- ↑ Schwarz, S., Elger, W., Siemann, H. J., Reddersen, G., & Schneider, B. (2000). U.S. Patent No. 6,080,735. Washington, DC: U.S. Patent and Trademark Office. https://patents.google.com/patent/US6080735A/en
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
