Английская Википедия:Etifoxine

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Шаблон:Short description Шаблон:Drugbox Etifoxine, sold under the trade name Stresam among others, is a nonbenzodiazepine anxiolytic agent, primarily indicated for short-term management of adjustment disorder, specifically instances of situational depression accompanied by anxiety, such as stress-induced anxiety.[1][2] Administration is by mouth.[3] Side effects associated with etifoxine use include slight drowsiness, headache, skin eruptions, and allergic reactions.[1][4][5] In rare cases, etifoxine has been linked to severe skin and liver toxicity, as well as menstrual bleeding between periods.[4][6] Unlike benzodiazepines, etifoxine does not cause sedation or lack of coordination.[7][8] Etifoxine acts as a GABAA receptor positive allosteric modulator and as a ligand for translocator proteins.[7] Both mechanisms are conjectured to contribute to its anxiolytic properties.[7][8]

Etifoxine was developed in the 1960s and was introduced for medical use in France in 1979.[9] Its marketed in 53 countries worldwide, although it remains unavailable in the United States.[3][9][10] Throughout the 2010s and early 2020s, the safety profile of etifoxine was scrutinized within France and the European Union, prompted by reports of toxicity.[11][4][3] The investigation revealed that instances of toxicity were infrequent, and etifoxine was allowed to remain on the market.[11][4][3]

Medical uses

Etifoxine has historically been used in the treatment of "psychosomatic manifestations of anxiety", for instance "autonomic dystonia, particularly with cardiovascular expression".[3][11][4][6] Subsequently, the indication for etifoxine has been more formalized as treatment of adjustment disorder (situational depression) with anxiety (ADWA) (e.g., stress-related anxiety).[3][12][8] Etifoxine has been found to reduce scores on the Hamilton Anxiety Rating Scale (HAM-A) in people with adjustment disorder with anxiety by approximately 50 to 75% after 4Шаблон:Nbspweeks of treatment in clinical trials (e.g., AMETIS, ETILOR, ETIZAL, STRETI studies).[3] The medication is similarly effective or more effective than benzodiazepines like lorazepam, alprazolam, and clonazepam and more effective than buspirone for adjustment disorder with anxiety on the basis of directly comparative randomized controlled trials.[12][8][13][14][15][16] However, in the AMETIS study, both etifoxine and lorazepam failed to show greater effectiveness over placebo.[3]

The usual dosage of etifoxine (as the hydrochloride salt) is 150 to 200Шаблон:Nbspmg per day in divided doses of 50 to 100Шаблон:Nbspmg two to three times per day (e.g., 50Шаблон:Nbspmg–50Шаблон:Nbspmg–100Шаблон:Nbspmg).[1][3][2][17][6][18][19] It is taken for a few days to a few weeks, but no longer than 12Шаблон:Nbspweeks.[1][11][3][20]

Available forms

Etifoxine is provided in the form of oral capsules containing 50Шаблон:Nbspmg etifoxine hydrochloride.[1][6][21][22]

Contraindications

Etifoxine is contraindicated in people with circulatory shock, severe liver impairment, severe kidney impairment, myasthenia gravis, galactosemia (due to lactose in the drug formulation), severe respiratory failure, and hypersensitivity (allergy) to etifoxine.[1][20] The medication is not recommended in children or adolescents under the age of 18[20] and is not recommended during pregnancy and breastfeeding due to insufficient data.[1][6] Caution is warranted with regard to combining etifoxine and other central depressants such as benzodiazepines, central analgesics, antipsychotics, sedative antihistamines, and alcohol.[1][6]

Side effects

Side effects of etifoxine include slight drowsiness and headache.[1][5] Rarely, etifoxine can cause benign skin eruptions or rashes and allergic reactions such as hives and angioedema.[1][4][6] Etifoxine shows less adverse effects of anterograde amnesia, sedation, impaired psychomotor performance, and withdrawal syndromes than those of benzodiazepines.[20] No cases of misuse or dependence with etifoxine were identified in a French pharmacovigilance survey, which is also in contrast to benzodiazepines.[4]

Etifoxine has been associated rarely with cases of severe dermal toxicity and liver toxicity.[4][23] Skin and subcutaneous disorders are the most frequently reported, but these generally resolve after drug cessation.[8] A 2012 review of etifoxine by the French National Pharmacovigilance Committee determined that etifoxine was safe and continued to provide a favorable alternative to benzodiazepine anxiolytics. The committee found (for a ten-year pharmacovigilance period) that safety concerns were rare or very rare and that the incidence of idiosyncratic hepatic (liver) problems were very rare.[11]

Pharmacology

Pharmacodynamics

Unlike benzodiazepines, etifoxine may produce its anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors and (purportedly, exact binding site undetermined) to the mitochondrial translocator protein (TSPO). This results in stimulation of the biosynthesis of endogenous neurosteroids, for instance allopregnanolone, a highly potent GABAA receptor positive allosteric modulator.[24]

At GABAA receptors etifoxine binds at the α+β− interface and preferentially potentiates α2β3γ2 and α3β3γ2 receptor types.[25] This direct allosteric potentiation can only be observed at relatively high concentrations (starting at >1Шаблон:NbspmM) and is perhaps not physiologically relevant at normal human doses.[26] This is different from benzodiazepines and etifoxine can be used alongside benzodiazepines to potentiate their effects without competing for binding sites;[27] however, it also means that the direct effects of etifoxine are not reversed by the benzodiazepine antagonist flumazenil.[28]

Pharmacokinetics

Etifoxine is taken via oral administration.[1][20] It is rapidly absorbed from the gastrointestinal tract.[20] It is well-absorbed, with a bioavailability of 90%.[1][8] The time to peak levels of etifoxine is 2 to 3Шаблон:Nbsphours.[20] The plasma protein binding of etifoxine is 88 to 95%.[16] It does not bind to blood cells.[1] The drug is known to cross the placental barrier.[1] Etifoxine is metabolized in the liver into several metabolites.[20] One of these metabolites, diethyletifoxine, is pharmacologically active.[20] The elimination half-life of etifoxine is 6Шаблон:Nbsphours and of diethyletifoxine is almost 20Шаблон:Nbsphours.[20] Etifoxine is eliminated in three phases.[1] The drug is excreted mainly in urine in the form of metabolites.[20] It is also excreted in bile.[20] Only small amounts are excreted unchanged.[20]

Chemistry

Etifoxine is a nonbenzodiazepine—that is, it is similarly a GABAA receptor positive allosteric modulator but its chemical structure is distinct from that of benzodiazepines.[8][29] Instead, it is a benzoxazine derivative.[8]

Etifoxine is used pharmaceutically as the hydrochloride salt.[30][31]

(S)-Etifoxine, the (S) enantiomer of etifoxine, was under development by Anvyl Pharmaceuticals for the treatment of neuropathic pain, but development was discontinued.[32] A deuterated form of etifoxine with improved pharmacokinetics known as deuterated etifoxine (GRX-917) is under development by GABA Therapeutics for the treatment anxiety and mood disorders.[33][34][24][35]

History

Etifoxine was developed by Hoechst in the 1960s.[9][36] It was introduced for medical use in France in 1979.[9] Since at least 2000, etifoxine has been marketed by the French pharmaceutical company Biocodex.[31][29][37][18] Following reports of post-marketing toxicity, the safety of etifoxine was reassessed by the French government[11][4] and the European Medicines Agency (EMA).[38][39] In January 2022, the EMA "finalized its review of Stresam and concluded that the medicine can continue to be used for the treatment of anxiety disorders, but it must not be used in patients who previously had severe skin reactions or severe liver problems after taking etifoxine."[38][39]

Society and culture

Names

Etifoxine is the generic name of the drug and its Шаблон:Abbrlink, Шаблон:Abbrlink, and Шаблон:Abbrlink.[30][31] It is also known by the older and much-lesser-used synonym etafenoxine[40] and by its developmental code name Hoe 36801.[30][31] Etifoxine is marketed under the brand name Stresam.[30][31][18] It has also been marketed under the brand name Strezam, specifically in Russia.[18]

Availability

Etifoxine has been marketed in 53Шаблон:Nbspcountries as of 2022.[3][9] Some of the countries in which etifoxine has been marketed include Argentina, Bulgaria, Chile, France, Luxembourg, Malta, Romania, Russia, South Africa, Thailand, and Ukraine.[18][11][3][31] Etifoxine is not approved for use by the United States Food and Drug Administration (FDA) or the European Medicines Agency (EMA) of the European Union, and hence is not marketed in these regions.[9][3] However, etifoxine is marketed in five European Union member states (France, Bulgaria, Luxembourg, Malta, Romania).[11][3]

See also

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

Шаблон:Anxiolytics Шаблон:GABAA receptor positive allosteric modulators Шаблон:Translocator protein modulators

Партнерские ресурсы
Криптовалюты
Магазины
Хостинг
Разное

  1. ↑ 1,00 1,01 1,02 1,03 1,04 1,05 1,06 1,07 1,08 1,09 1,10 1,11 1,12 1,13 1,14 Шаблон:Cite web
  2. ↑ 2,0 2,1 Шаблон:Cite journal
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 Шаблон:Cite web
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 4,6 4,7 4,8 Шаблон:Cite journal
  5. ↑ 5,0 5,1 Шаблон:Cite journal
  6. ↑ 6,0 6,1 6,2 6,3 6,4 6,5 6,6 Шаблон:Cite book
  7. ↑ 7,0 7,1 7,2 Шаблон:Cite journal
  8. ↑ 8,0 8,1 8,2 8,3 8,4 8,5 8,6 8,7 Шаблон:Cite journal
  9. ↑ 9,0 9,1 9,2 9,3 9,4 9,5 Шаблон:Cite journal
  10. ↑ Шаблон:Cite web
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 11,6 11,7 Шаблон:Cite web
  12. ↑ 12,0 12,1 Шаблон:Cite journal
  13. ↑ Шаблон:Cite journal
  14. ↑ Шаблон:Cite journal
  15. ↑ Шаблон:Cite journal
  16. ↑ 16,0 16,1 Шаблон:Cite journal
  17. ↑ Шаблон:Cite journal
  18. ↑ 18,0 18,1 18,2 18,3 18,4 Шаблон:Cite web
  19. ↑ Шаблон:Cite journal
  20. ↑ 20,00 20,01 20,02 20,03 20,04 20,05 20,06 20,07 20,08 20,09 20,10 20,11 20,12 Шаблон:Cite journal
  21. ↑ Шаблон:Cite book
  22. ↑ Шаблон:Cite book
  23. ↑ Шаблон:Cite journal
  24. ↑ 24,0 24,1 Шаблон:Cite journal
  25. ↑ Шаблон:Cite journal
  26. ↑ Шаблон:Cite journal
  27. ↑ Шаблон:Cite journal
  28. ↑ Шаблон:Cite journal
  29. ↑ 29,0 29,1 Шаблон:Cite journal
  30. ↑ 30,0 30,1 30,2 30,3 Шаблон:Cite book
  31. ↑ 31,0 31,1 31,2 31,3 31,4 31,5 Шаблон:Cite book
  32. ↑ Шаблон:Cite web
  33. ↑ Шаблон:Cite web
  34. ↑ Шаблон:Cite journal
  35. ↑ Шаблон:Cite journal
  36. ↑ Шаблон:US Patent
  37. ↑ Шаблон:Cite journal
  38. ↑ 38,0 38,1 Шаблон:Cite web
  39. ↑ 39,0 39,1 Шаблон:Cite web
  40. ↑ Шаблон:Cite journal
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