Английская Википедия:FKBP2

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Версия от 02:28, 6 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''FK506-binding protein 2''' is a protein that in humans is encoded by the ''FKBP2'' gene.<ref name="pmid1713687">{{cite journal | vauthors = Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ | title = Molecular cloning of a membrane-associated human FK506- and rapamycin-bindi...»)
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Шаблон:Short description Шаблон:Infobox gene FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[1][2]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[2]

Interactions

FKBP2 has been shown to interact with ARFGEF1[3] and EPB41L2.[4]

References

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Further reading

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  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite web
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:FKBP2&oldid=14642249