Английская Википедия:FKBP3
Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.[1][2][3]
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[4][3]
Interactions
FKBP3 has been shown to interact with YY1,[5] HDAC1,[5] Histone deacetylase 2,[5] DNA,[6] and Mdm2.[7] Both crystal structure of FKBP25 with FK506 and the NMR structure of full length FKBP25 has been published with PDB ID 5D75 and 2MPH respectively.[4][8]
References
Further reading
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Peptidyl-prolyl cis-trans isomerase FKBP3
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Peptidyl-prolyl cis-trans isomerase FKBP3
Шаблон:Geometric isomerases Шаблон:Enzymes Шаблон:Portal bar
