Английская Википедия:Fluoroacetic acid
Шаблон:Chembox Fluoroacetic acid is a organofluorine compound with formula CH2FCO2H. It is a colorless solid that is noted for its relatively high toxicity.[1] The conjugate base, fluoroacetate occurs naturally in at least 40 plants in Australia, Brazil, and Africa. It is one of only five known organic fluorine-containing natural products.[2]
Toxicity
Fluoroacetic acid is a harmful metabolite of some fluorine-containing drugs (median lethal dose, LD50 = 10 mg/kg in humans). The most common metabolic sources of fluoroacetic acid are fluoroamines and fluoroethers. Fluoroacetic acid can disrupt the Krebs cycle.[3]
In contrast with monofluoroacetic acid, difluoroacetic acid and trifluoroacetic acid are far less toxic. Its pKa is 2.66, in contrast to 1.24 and 0.23 for the respective di- and trifluorinated acids.[4]
Uses
Fluoroacetic acid is used to manufacture pesticides especially rodenticides (see sodium fluoroacetate). The overall market is projected to rise at a considerable rate during the forecast period, 2021 to 2027.[5]
See also
References
- Английская Википедия
- Carboxylic acids
- Organofluorides
- Halogen-containing natural products
- Respiratory toxins
- Fluorine-containing natural products
- Aconitase inhibitors
- Fluoroacetates
- Fluorinated carboxylic acids
- Plant toxins
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