Английская Википедия:Frizzled-4

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Версия от 09:26, 10 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Frizzled-4''' '''(Fz-4)''' is a protein that in humans is encoded by the ''FZD4'' gene.<ref name="pmid10544037">{{cite journal | vauthors = Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-4 on chromos...»)
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Шаблон:Short description Шаблон:Infobox gene Frizzled-4 (Fz-4) is a protein that in humans is encoded by the FZD4 gene.[1][2][3] Fz-4 has also been designated as CD344 (cluster of differentiation 344).

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins.[4] FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.[3]

See also

References

Шаблон:Reflist


Further reading

Шаблон:Refbegin

Шаблон:Refend

External links


Шаблон:Transmembranereceptor-stub Шаблон:NLM content Шаблон:Clusters of differentiation Шаблон:G protein-coupled receptors

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  1. ↑ Шаблон:Cite journal
  2. ↑ Шаблон:Cite journal
  3. ↑ 3,0 3,1 Шаблон:Cite web
  4. ↑ Шаблон:Cite journal
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