Английская Википедия:Frizzled-7

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Версия от 09:26, 10 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Frizzled-7''' '''(Fd-7)''' is a protein that in humans is encoded by the ''FZD7'' gene.<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin sig...»)
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Шаблон:Short description Шаблон:Infobox gene Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]

Interactions

Fz-7 has been shown to interact with DLG4.[4]

References

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Further reading

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External links

Шаблон:NLM content Шаблон:G protein-coupled receptors Шаблон:Transmembranereceptor-stub