Английская Википедия:Frizzled-8

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Версия от 09:26, 10 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Frizzled-8''' '''(Fz-8)''' is a protein that in humans is encoded by the ''FZD8'' gene.<ref name="pmid11295046">{{cite journal |vauthors=Saitoh T, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2 | journal = Int J Oncol | volu...»)
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Шаблон:Short description Шаблон:Infobox gene Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.[1][2]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

References

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Further reading

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External links


Шаблон:PDB Gallery Шаблон:G protein-coupled receptors

Шаблон:NLM content Шаблон:Transmembranereceptor-stub