Английская Википедия:Furonazide
Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C.[1]
Synthesis
Furonazide was first prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product.[1][2]
Applications
Furonazide has shown bacteriostatic action and is tuberculostatic at levels of 10−8 molar.[1] The in vitro antibacterial activity of furonazide against Bacillus Calmette-Guerin was found to be essentially equal to that of isoniazid on an equimolar basis.[3] In vivo studies in the guinea pig showed furonazide slightly more active than isoniazid as a tuberculostatic agent.[4] The drug has relatively low toxicity. The median lethal dose (LD50, rat oral) was reported as 2,600 mg/kg.[5]
References
- ↑ 1,0 1,1 1,2 Kazuo Miyatake, “Derivatives of isonicotinic acid hydrazide”, Japanese Patent 32,002,484 B4 (1957)
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ "Drugs - Synonyms and Properties" data were obtained from Ashgate Publishing Co. (US)
