Английская Википедия:GABBR1

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Версия от 21:26, 10 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Gamma-aminobutyric acid B receptor, 1''' ('''GABA<sub>B1</sub>'''), is a G-protein coupled receptor subunit encoded by the ''GABBR1'' gene. == Function == '''GABA<sub>B1</sub>''' is a receptor for Gamma-aminobutyric acid. Upon binding, GABA<sub>B1</sub> will p...»)
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Шаблон:Short description Шаблон:Infobox gene Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Function

GABAB1 is a receptor for Gamma-aminobutyric acid. Upon binding, GABAB1 will produce a slow and prolonged inhibitory effect. GABAB1 is one part of a heterodimer, which is the GABAB receptor, consisting of it and the related GABAB2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[1]

Interactions

GABBR1 has been shown to interact with ATF4[2] and GABBR2.[3]

See also

References

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Further reading

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External links

Шаблон:PDB Gallery Шаблон:G protein-coupled receptors Шаблон:NLM content Шаблон:Transmembranereceptor-stub