Английская Википедия:GPR139
Материал из Онлайн справочника
Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene.[1][2] Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.[3][4]
Ligands
- Agonists
- Zelatriazin (TAK-41), (NBI-1065846) a potent, and GPR139 receptor selective agonist [5] which was in clinical trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia, but was later dropped from development.
- Antagonists
References
Further reading
Шаблон:G protein-coupled receptors Шаблон:Transmembranereceptor-stub
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
- ↑ Vedel L, Nøhr AC, Gloriam DE, Bräuner-Osborne H. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. Шаблон:Doi Шаблон:PMID
- ↑ Шаблон:Cite journal