Английская Википедия:GPR158
Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene
Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[1] is a protein that in humans is encoded by the GPR158 gene.[2]
Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[3]
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[4]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[5]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[6]
References
Шаблон:G protein-coupled receptors
Шаблон:Transmembranereceptor-stub
