Английская Википедия:GRID1
Шаблон:Short description Шаблон:Infobox gene
Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein[1][2] (1009 aa) encoded by the GRID1 gene.[3][4] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[5]
Function
This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system[6] and is important in synaptic plasticity.[3][7]
Clinical significance
Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[8][9]
See also
References
Further reading
Шаблон:Ligand-gated ion channels
