Английская Википедия:Gastrin-releasing peptide receptor

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Версия от 16:05, 11 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{other uses|BB2 (disambiguation)}} {{Infobox_gene}} The '''gastrin-releasing peptide receptor''' ('''GRPR'''), now properly known as '''BB<sub>2</sub>''' <ref name="IUPHAR-DB">{{cite web | url = https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=39 | title = Bombesin Receptors: BB<sub>2</sub> |...»)
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Шаблон:Short description Шаблон:Other uses Шаблон:Infobox gene

The gastrin-releasing peptide receptor (GRPR), now properly known as BB2 [1] is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide.[2] In humans it is highly expressed in the pancreas and is also expressed in the stomach, adrenal cortex and brain.[3]

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.[4]

The transcription factor CREB is a regulator of human GRP-R expression in colon cancer.[5]

Activation MOR1D‐GRPR heteromers in the spinal cord mediate the common troublesome opioid-induced itch.

References

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Further reading

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External links

Шаблон:NLM content Шаблон:G protein-coupled receptors

Шаблон:Transmembranereceptor-stub

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  1. ↑ Шаблон:Cite web
  2. ↑ Шаблон:Cite journal
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite web
  5. ↑ Шаблон:Cite journal
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