Английская Википедия:Glycylpeptide N-tetradecanoyltransferase
Шаблон:Infobox enzyme Шаблон:Pfam box Шаблон:Pfam box
In enzymology, a glycylpeptide N-tetradecanoyltransferase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction
- tetradecanoyl-CoA + glycylpeptide <math>\rightleftharpoons</math> CoA + N-tetradecanoylglycylpeptide
Thus, the two substrates of this enzyme are tetradecanoyl-CoA and glycylpeptide, whereas its two products are CoA and N-tetradecanoylglycylpeptide. It participates in the N-Myristoylation of proteins, and in vertebrates there are two isoenzymes NMT1 and NMT2.
Besides tetradecanoyl-CoA, this enzyme is also capable of using modified versions of this substrate.[1] In human retina, an even wider range of fatty acids, including 14:1 n–9, 14:2n–6, and 12:0, are accepted by the enzyme and grafted onto guanylate cyclase activators.[2] This is mainly a result of a special set of fatty-acid-CoA substrates available in the retina.[3]
Nomenclature
This enzyme belongs to the family of transferases, specifically those N-acyltransferases transferring groups other than aminoacyl groups (cd04301). The systematic name of this enzyme class is tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase. Other names in common use include peptide N-myristoyltransferase (NMT), myristoyl-CoA-protein N-myristoyltransferase, myristoyl-coenzyme A:protein N-myristoyl transferase, myristoylating enzymes, and protein N-myristoyltransferase.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.
The enzyme folds into two domains, each with a double EF-hand arrangement.
References
Шаблон:Acyltransferases Шаблон:Enzymes Шаблон:Portal bar
