Английская Википедия:Golgi reassembly-stacking protein 1

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Версия от 20:09, 15 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Golgi reassembly-stacking protein 1''' ('''GORASP1''') also known as '''Golgi reassembly-stacking protein of 65 kDa''' ('''GRASP65''') is a protein that in humans is encoded by the ''GORASP1'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: GORASP1 golgi reassembly stacking prot...»)
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Шаблон:Short description Шаблон:Infobox gene Golgi reassembly-stacking protein 1 (GORASP1) also known as Golgi reassembly-stacking protein of 65 kDa (GRASP65) is a protein that in humans is encoded by the GORASP1 gene.[1]

Function

Файл:GRASP65antic.jpg
Microinjection of antibodies to GORASP1 prevents normal Golgi stack formation.[2]

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The GORASP1 protein is a peripheral membrane protein anchored to the lipid bilayer through myristoylation of a glycine residue near the protein's amino terminus.[3] It is involved in establishing the stacked structure of the Golgi apparatus and linking the stacks into larger ribbons in vertebrate cells.[3] It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis.[4][5] GORASP1 can form a complex with the Golgi matrix protein GM130, and this complex binds to the vesicle docking protein p115.[3]Шаблон:Efn Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.[1]

Structure

GORASP1 contains two PDZ domains in the amino-terminal GRASP domain (amino acid residues 2–210), that comprises approximately half of the protein. The GRASP region interacts with the Golgi matrix protein GM130 as well as an intrinsically disordered region in the C-terminus.[3][6]

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Interactions

GORASP1 has been shown to interact with TGF alpha,[7] TMED2[7] and GOLGA2.[7][8][9]

Notes

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References

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Further reading

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External links


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  1. ↑ 1,0 1,1 Шаблон:Cite web
  2. ↑ Шаблон:Cite journal
  3. ↑ 3,0 3,1 3,2 3,3 Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
  6. ↑ Шаблон:Cite journal
  7. ↑ 7,0 7,1 7,2 Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:Golgi_reassembly-stacking_protein_1&oldid=14983656