Английская Википедия:Gq-mER

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Версия от 08:04, 16 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} The '''G<sub>q</sub>-coupled membrane estrogen receptor''' ('''G<sub>q</sub>-mER''') is a G protein-coupled receptor present in the hypothalamus that has not yet been cloned.<ref name="Qiu2006">{{cite journal | vauthors = Qiu J, Bosch MA, Tobias SC, Krust A, Graham SM, Murphy SJ, Korach KS, Chambon P, Scanlan TS, Rønnekleiv OK, Kelly MJ | display-authors = 6 | title = A G-prot...»)
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The Gq-coupled membrane estrogen receptor (Gq-mER) is a G protein-coupled receptor present in the hypothalamus that has not yet been cloned.[1][2] It is a membrane-associated receptor that is Gq-coupled to a phospholipase C–protein kinase C–protein kinase A (PLC–PKC–PKA) pathway.[1][2] The receptor has been implicated in the control of energy homeostasis.[1] Gq-mER is bound and activated by estradiol, and is a putative membrane estrogen receptor (mER).[1][2] A nonsteroidal diphenylacrylamide derivative, STX, which is structurally related to 4-hydroxytamoxifen (afimoxifene), is an agonist of the receptor with greater potency than estradiol (20-fold higher affinity) that has been discovered.[1][2][3] Fulvestrant (ICI-182,780) has been identified as an antagonist of Gq-mER, but is not selective.[3]

See also

References

Шаблон:Reflist

Шаблон:G protein-coupled receptors Шаблон:Estrogenics

Шаблон:Transmembranereceptor-stub

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  1. ↑ 1,0 1,1 1,2 1,3 1,4 Шаблон:Cite journal
  2. ↑ 2,0 2,1 2,2 2,3 Шаблон:Cite journal
  3. ↑ 3,0 3,1 Шаблон:Cite journal
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