Английская Википедия:Granulovacuolar degeneration
Granulovacuolar degeneration refers to the occurrence within neurons of abnormal, fluid-filled bubbles (vacuoles) containing a dense proteinaceous granule.[1] Granulovacuoles occur most commonly in pyramidal neurons of the hippocampus. They are present in small numbers in non-demented elderly people, but increase in frequency in Alzheimer's disease and other tauopathies.[2] In Alzheimer's disease, granulovacuoles proliferate stage-wise in different brain areas, and their prevalence is correlated with the degree of tauopathy, Abeta plaque pathology, and cerebral amyloid angiopathy.[2] Immunohistochemical analyses have found that the inner granule includes several proteins, including tubulin[3] tau protein, TDP-43 and others.[2] Although granulovacuoles and their functional significance are still poorly understood, they have been compared to autophagic vacuoles [4]
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