Английская Википедия:Griseoxanthone C
Шаблон:Short description Шаблон:Chembox
Griseoxanthone C is an organic compound in the structural class of chemicals known as xanthones. Its chemical formula is 1,6-dihydroxy-3-methoxy-8-methylxanthen-9-one, and its molecular formula is C15H12O5. It is found in a plant and some fungi, including a lichen.
History
Griseoxanthone C was first isolated from the fungus Penicillium patulum by McMaster and colleagues in 1960. They were investigating the biosynthesis of the somewhat structurally related compound griseofulvin and discovered it in the residual material of the growth medium containing the fungi.[1] A year later, another group studying griseofulvin biosynthesis discovered that the production of griseoxanthone C could be induced by inhibiting the chlorination of griseophenone C (an intermediate in the biosynthetic pathway leading to griseofulvin), and that griseoxanthone C could be created chemically from griseophenone C.[2] Jayalakshmi and colleagues proposed a chemical synthesis of griseoxanthone C in 1974.[3]
Properties
In its purified form, griseoxanthone C exists as yellowish needles with a melting point of Шаблон:Convert. An ethanolic solution of griseoxanthone C reacts with iron(III) chloride to produce a violet-brown colour. Its ultraviolet spectrum has four peaks of maximum absorption (λmax) at 242, 269, 309, and 340 nm.[4]
In laboratory tests, griseoxanthone C showed strong antibiotic effects toward Bacillus subtilis and methicillin-resistant Staphylococcus aureus.[5] It also has strong cytotoxicity to Hep2 liver cancer cells in in vitro experiments.[6]
Occurrence
In 1992, John Elix and Caroline Crook reported griseoxanthone C from the lichen Lecanora vinetorum.[7] It has since been reported from various other species, including the flowers of the plant Ficus hookeriana,[8] the fungi Fusarium equiseti,[9] Penicillium concentricum,[10] and Urocladium.[5]
See also
References
- ↑ Ошибка цитирования Неверный тег
<ref>; для сносокMcMaster et al. 1960не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокRhodes et al. 1961не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокJayalakshmi et al. 1974не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокHuneck 1996не указан текст - ↑ 5,0 5,1 Ошибка цитирования Неверный тег
<ref>; для сносокWang et al. 2012не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокHawas et al. 2018не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокElix & Crook 1992не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокWei et al. 2012не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокHawas et al. 2016не указан текст - ↑ Ошибка цитирования Неверный тег
<ref>; для сносокAli et al. 2017не указан текст
