Английская Википедия:HIOC

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Версия от 04:01, 18 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Chemical compound}} {{Infobox drug | IUPAC_name = ''N''-[2-(5-Hydroxy-1''H''-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide | image = HIOC.svg | width = 225px | CAS_number = 314054-36-9 | ATC_prefix = None | ATC_suffix = | PubChem = 5012758 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = JC3KZQ72GW | DrugBank = | ChemSpiderID = 4192105 | chemical_formula = | C=16 |...»)
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HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM).[1][2][3] It was derived from N-acetylserotonin (NAS).[2][3][4] Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues).[2][3] It is described as producing long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor.[2] HIOC is systemically active and is able to penetrate the blood-brain-barrier.[2] In animal studies, HIOC was found to robustly protect against glutamate-induced excitotoxicity, an action which was TrkB-dependent.[3]

A chemical synthesis of HIOC was published in 2015.[5]

See also

References

Шаблон:Reflist

Шаблон:Growth factor receptor modulators Шаблон:Tryptamines


Шаблон:Nervous-system-drug-stub