Английская Википедия:HOCOMOCO
Шаблон:Short description Шаблон:Use dmy dates Шаблон:Infobox biodatabase
HOCOMOCO[1][2] [3][4] is an open-access database providing curated and benchmarked binding motifs of human and mouse transcription factors. It captures the following data types: Homo sapiens (human) and Mus musculus (mouse) transcription factors, their DNA binding site motifs, and motif subtypes.
Introduction
Transcription factors (TFs) are proteins that bind DNA and thus regulate the trasncription process. The binding is sequence-specific. A sequence motif[5] is a model that describes the common pattern of the DNA binding sites[6] that a particular TF prefers to bind. One of the possible representations of the model is the Position-Weight Matrix (PWM).[7]
Organisms
Recognition
According to the Web of Science, the 2018 publication of HOCOMOCO [2] has been cited 396 times (as of January 2024). The publications [3][4] have been cited 144 and 151 times.
See also
References
Шаблон:Reflist Шаблон:Authority control
