Английская Википедия:HSP90B1

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Версия от 10:44, 18 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Heat shock protein 90kDa beta member 1''' (HSP90B1), known also as '''endoplasmin''', '''gp96''', '''grp94''', or '''ERp99''', is a chaperone protein that in humans is encoded by the ''HSP90B1'' gene.<ref name="pmid2377606">{{cite journal | vauthors = Maki RG, Old LJ, Srivastava PK | title...»)
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Шаблон:Short description Шаблон:Infobox gene Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene.[1][2]

HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins.[3][4] It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity.[5] Tumor-derived HSP90B1 (vitespen) has entered clinical trials for cancer immunotherapy.[6][7][8][9]

grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic cancer. grp94 includes 5 distinct amino acids in its primary sequence which creates 2 unique sub-pockets, S1 and S2. These sub-pockets have been utilized in current research in order to inhibit the chaperone since its client proteins seem to be up-regulated in cancer cells.[10]

References

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Further reading

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