Английская Википедия:HSPB7
Шаблон:Short description Шаблон:Infobox gene Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.[1],.[2] HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da.[3] HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins.[4] HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.[5]
Expression and molecular function
HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue [4],.[6] HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases.[7] Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones.[7] In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3.[5] An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins [5],[8]
Role in cardiomyopathy and Cancer
HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies.[7] It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis.[9] Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines[5],.[10] The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells.[5] In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma.[10]
| Approved Symbol | HSPB7 |
|---|---|
| Approved Name | Heat shock protein family B (small) member 7 |
| HGNC ID | HGNC:5249 |
| Previous name | heat shock 27kD protein family, member 7 (cardiovascular) |
| Alias Symbols | cvHSP |
| Chromosome location | 1p36.13 |
| Ensembl | ENSG00000173641 |
| UniProt | Q9UBY9 |
| NCBI Gene | 27129 |
| RefSeq | NM_014424 |
| UCSC | uc001axo.2 |
| Protein Sequence | HSPB7 Protein Sequence (Ensembl) |
| Wikidata | Q18038659 |
| PubMed | HSPB7 PubMed References |
References
