Английская Википедия:Hemoglobin subunit alpha

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Версия от 14:32, 20 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{cs1 config|name-list-style=vanc}} {{Short description|Human hemoglobin protein}} {{Infobox_gene}} '''Hemoglobin subunit alpha''', Hemoglobin, alpha 1,<ref>{{Cite web|url=https://medlineplus.gov/genetics/gene/hba1/|title = HBA1 gene: MedlinePlus Genetics}}</ref> is a hemoglobin protein that in humans is encoded by the ''HBA1'' gene.<ref name = "entrez"/> ==...»)
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Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene Hemoglobin subunit alpha, Hemoglobin, alpha 1,[1] is a hemoglobin protein that in humans is encoded by the HBA1 gene.[2]

Gene

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1; this gene) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.[2]

Protein

Two alpha chains plus two beta chains constitute HbA, which in normal adult life accounts for about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with fetal hemoglobin (HbF), composed of alpha and gamma chains, make up the remaining 3% of adult hemoglobin.[2]

Clinical significance

Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.[2]

Interactions

Hemoglobin subunit alpha has been shown to interact with hemoglobin subunit beta (HBB).[3][4]

See also

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

Шаблон:PDB Gallery Шаблон:Hemeproteins

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  1. ↑ Шаблон:Cite web
  2. ↑ 2,0 2,1 2,2 2,3 Шаблон:Cite web
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
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