Английская Википедия:Hemolin
Hemolin is an immunoglobulin-like protein exclusively found in Lepidoptera (moths and butterflies). It was first discovered in immune-challenged pupae of Hyalophora cecropia[1] and Manduca sexta.[2]
Hemolin has a horseshoe crystal structure[3] with four domains and resembles the developmental protein neuroglian.
Hemolin increases 18-fold up to 7 mg/ml following injection of bacteria in H. cecropia. Induction of Hemolin in moths after bacterial injection have been shown in several species including Antheraea pernyi,[4] Bombyx mori, Helicoverpa zea,[5] Heliothis virescens,[6] Hyphantria cunea,[7] and Samia cynthia.[8]
Hemolin has also been suggested to participate in the immune response to virus infection[9] and shown to bind to virus particles.[10] It is expressed in response to dsRNA in a dose-dependent manner.[11] Galleria melonella responds to caffeine intake by increased Hemolin protein expression.[12]
Hemolin is thought to be a gene duplication of the developmental protein neuroglian,[13] but has lost two of the protein domains that neuroglian contains. In the potential function as a developmental protein, Hemolin has been shown to increase close to pupation in Manduca sexta,[14] and is induced during diapause and by 20-Hydroxyecdysone in Lymantria dispar.[15] RNAi of Hemolin causes malformation in H. cecropia.[16]
See also
References
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
