Английская Википедия:Hepacivirus A
Шаблон:Short description Шаблон:Virusbox
Hepacivirus A, or Canine hepacivirus (CHV) or Equine hepacivirus (EHV), is a positive-sense single-stranded RNA virus of the genus Hepacivirus.[1] It infects dogs and horses, and causes pulmonary infections in dogs. Unlike the related Hepatitis C virus, it is not known to cause hepatitis in either host.
History
The virus was isolated in 2011 from a number of dogs suffering from respiratory infections. Later, distinct lineages were isolated from horses in different locations.Шаблон:Cn
Genome
As of 2012, the genome has not yet been fully sequenced. The available sequence is about 6,500 nucleotides in length. It is predicted to have a polyprotein that can be cleaved into 10 smaller proteins. There is a 'slippery sequence' – A5NNA5 – within the genome which may encode a programmed frameshift. It encodes two envelope proteins (E1 and E2) as well as cysteine and serine proteases.Шаблон:Cn
The overall G+C content is 50.7%.Шаблон:Cn
Evolution
The virus appears to have evolved from the Hepatitis C virus between 500 and 1,000 years ago.Шаблон:Cn
The equine lineages (EHV) are more diverse than the canine lineages (CHV), suggesting that the former are ancestral to the latter. CHV appears to have originated in a cross-species transmission from horses to dogs around 1970. The origin of EHV is not known, but it seems that both EHV and Hepatitis C virus have originated in separate cross-species transmission events from a common source.[2]
References
