Английская Википедия:Hesperadin
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Hesperadin is an aurora kinase inhibitor.
The small molecule inhibits chromosome alignment and segregation by limiting the function of mitotic kinases Aurora B and Aurora A. Hesperadin causes cells to enter anaphase much faster, sometimes before the chromosomes are properly bi-oriented.[1]
Hesperadin, like other miotic inhibitors, limits and sometimes can stop the process of mitosis in cells. For this reason, some have considered hesperadin's potential as a cancer-preventing drug.[2]
Hesperadin works as an inhibitor, attaching to the active sites of Aurora A and Aurora B kinases.[2]
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