Английская Википедия:Host cell factor C1

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Версия от 01:20, 23 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Host cell factor 1''' ('''HCFC1''', '''HCF1''', or '''HCF-1'''), also known as '''VP16-accessory protein''',<ref>[http://genecards.org/cgi-bin/carddisp.pl?gene=HCFC1 GeneCards entry for HCFC1], http://genecards.org {{webarchive|url=https://web.archive.org/web/20131014090047/http://www.genecards.or...»)
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Шаблон:Short description Шаблон:Infobox gene Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,[1] is a protein that in humans is encoded by the HCFC1 gene.[2][3]

Structure

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function

HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant.[4] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]

Mutations in this gene have been linked to disorders of the cobalamine metabolism.[5]

Interactions

Host cell factor C1 has been shown to interact with: Шаблон:Div col

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References

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Further reading

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  1. ↑ GeneCards entry for HCFC1, http://genecards.org Шаблон:Webarchive
  2. ↑ Шаблон:Cite journal
  3. ↑ 3,0 3,1 Шаблон:Cite web
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
  6. ↑ Шаблон:Cite journal
  7. ↑ Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ 10,0 10,1 10,2 10,3 10,4 10,5 10,6 Шаблон:Cite journal
  11. ↑ 11,0 11,1 11,2 Шаблон:Cite journal
  12. ↑ Шаблон:Cite journal
  13. ↑ Шаблон:Cite journal
  14. ↑ Шаблон:Cite journal
  15. ↑ Шаблон:Cite journal
  16. ↑ Шаблон:Cite journal
  17. ↑ Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:Host_cell_factor_C1&oldid=15293282