Английская Википедия:Human coronavirus 229E

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Версия от 15:42, 23 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Species of virus}} {{Virusbox | image = Human coronavirus 229E.png | image_alt = | image_caption = Transmission electron micrograph of human coronavirus 229E | parent = Duvinacovirus | species = Human coronavirus 229E | synonyms = | synonyms_ref = }} '''''Human coronavirus 229E''''' ('''''HCoV-229E''''') is a species of coronavirus which infects humans a...»)
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Human coronavirus 229E (HCoV-229E) is a species of coronavirus which infects humans and bats.[1] It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor.[2] Along with Human coronavirus OC43 (a member of the Betacoronavirus genus), it is one of the viruses responsible for the common cold.[3][4] HCoV-229E is a member of the genus Alphacoronavirus and subgenus Duvinacovirus.[5][6]

Transmission

HCoV-229E transmits via droplet-respiration and fomites.

Signs and symptoms

HCoV-229E is associated with a range of respiratory symptoms, ranging from the common cold to high-morbidity outcomes such as pneumonia and bronchiolitis. However, such high morbidity outcomes are almost always seen in cases with co-infection with other respiratory pathogens; there is a single published case report to date of a 229E infection that caused acute respiratory distress syndrome (ARDS) in an otherwise healthy patient having no detectable co-infection with another pathogen.[7] HCoV-229E is also among the coronaviruses most frequently codetected with other respiratory viruses, particularly with human respiratory syncytial virus (HRSV).[8][9][10]

Epidemiology

HCoV-229E is one of the seven human coronaviruses which include HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, SARS-CoV-1, and SARS-CoV-2 and are globally distributed.[11][12] However, the viruses were detected in different parts of the world at different times of the year.[13][14][15] A NCBI-study found a previous HCoV-229E infection in 42.9% – 50.0% of children of 6–12 months of age and in 65% of those 2.5–3.5 years of age.[16]

Virology

HCoV-229E is one of seven known coronaviruses to infect humans. The other six are:[17]

Research

Шаблон:Missing information Chloroquine, a zinc ionophore, inhibits the replication of Human coronavirus 229E in cell culture.[18]

Human HCoV-229E, and human HCoV-NL63, likely originated from bats.[19]

History

A researcher at the University of Chicago, Dorothy Hamre, first identified 229E in 1965.[20][21]

See also

References

Шаблон:Reflist

External links

Шаблон:Wikispecies

Шаблон:Human coronaviruses Шаблон:Viral diseases Шаблон:Taxonbar

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  1. ↑ Шаблон:Cite journal
  2. ↑ Шаблон:Cite book
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite web
  6. ↑ Шаблон:Cite journal
  7. ↑ Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ Шаблон:Cite journal
  11. ↑ Fields, B. N., D. M. Knipe, and P. M. Howley (ed.). 1996. Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, PA.
  12. ↑ Шаблон:Cite journal
  13. ↑ Шаблон:Cite journal
  14. ↑ Шаблон:Cite journal
  15. ↑ Шаблон:Cite journal
  16. ↑ Шаблон:Cite journal
  17. ↑ Шаблон:Cite web
  18. ↑ Шаблон:Cite journal
  19. ↑ Шаблон:Cite journal
  20. ↑ Шаблон:Cite web
  21. ↑ Шаблон:Cite journal
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