Английская Википедия:ICAM2

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Версия от 08:16, 24 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Use dmy dates|date=April 2023}} {{Infobox_gene}} '''Intercellular adhesion molecule 2''' ('''ICAM2'''), also known as '''CD102''' ('''C'''luster of '''D'''ifferentiation 102), is a human gene, and the protein resulting from it. ==Protein structure== The protein encoded by this gene is a member of the interce...»)
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Шаблон:Short description Шаблон:Use dmy dates Шаблон:Infobox gene Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.[1]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[2]

Interactions

ICAM2 has been shown to interact with EZR.[3] It has also been shown to bind to P9 (Uniprot: B2UM07), a secreted protein from Akkermansia muciniphila.[4]

See also

References

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Further reading

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External links

  • Шаблон:MeshName
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Intercellular adhesion molecule 2 (ICAM2)

Шаблон:PDB Gallery Шаблон:Clusters of differentiation

Шаблон:NLM content


Шаблон:Membrane-protein-stub

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  1. ↑ Шаблон:Cite journal
  2. ↑ Шаблон:Cite web
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:ICAM2&oldid=15346858