Английская Википедия:Inositol monophosphatase 1

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Версия от 05:14, 26 марта 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Inositol monophosphatase 1''' is an enzyme that in humans is encoded by the ''IMPA1'' gene.<ref name="pmid1377913">{{cite journal |vauthors=McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI | title = cDNA cloning...»)
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Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.[1][2]

Interacting partners

IMPA1 has been shown to interact with Bergmann glial S100B[3] and calbindin.[4][5]

Chemical inhibitors

L-690,330 is a competitive inhibitor of IMPase activity with very good activity in vitro however with limited bioavailability in vivo.[6] Due to its increased specificity compared to Lithium, L-690,330 has been used extensively in characterizing the results of IMPase inhibition in various cell culture models. L-690,488, a prodrug or L-690,330, has also been developed which has greater cell permeability. Treatment of cortical slices with L-690,488 resulted in accumulation of inositol demonstrating the activity of this inhibitor in tissue.[7]

Inhibition of IMPA1 activity can have pleiotropic effects on cellular function, including altering phosphoinositide signalling,[8] autophagy, apoptosis,[9] and other effects.

Bipolar disorder

Initially it was noticed that several drugs useful in treatment of bipolar disorder such as lithium, carbamazepine and valproic acid had a common mechanism of action on enzymes in the phosphatidylinositol signalling pathway[10] and the inositol depletion hypothesis for the pathophysiology of bipolar disorder was suggested. Intensive research has so far not confirmed this hypothesis, partly because lithium can also act on a number of other enzymes in this pathway, complicating results from in vitro studies.

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Inositol monophosphatase 1

Шаблон:PDB Gallery Шаблон:Esterases Шаблон:Enzymes Шаблон:Portal bar

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  1. ↑ Шаблон:Cite journal
  2. ↑ Шаблон:Cite web
  3. ↑ Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
  6. ↑ Шаблон:Cite journal
  7. ↑ Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ Шаблон:Cite journal
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