Английская Википедия:Inositol monophosphatase 1
Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.[1][2]
Interacting partners
IMPA1 has been shown to interact with Bergmann glial S100B[3] and calbindin.[4][5]
Chemical inhibitors
L-690,330 is a competitive inhibitor of IMPase activity with very good activity in vitro however with limited bioavailability in vivo.[6] Due to its increased specificity compared to Lithium, L-690,330 has been used extensively in characterizing the results of IMPase inhibition in various cell culture models. L-690,488, a prodrug or L-690,330, has also been developed which has greater cell permeability. Treatment of cortical slices with L-690,488 resulted in accumulation of inositol demonstrating the activity of this inhibitor in tissue.[7]
Inhibition of IMPA1 activity can have pleiotropic effects on cellular function, including altering phosphoinositide signalling,[8] autophagy, apoptosis,[9] and other effects.
Bipolar disorder
Initially it was noticed that several drugs useful in treatment of bipolar disorder such as lithium, carbamazepine and valproic acid had a common mechanism of action on enzymes in the phosphatidylinositol signalling pathway[10] and the inositol depletion hypothesis for the pathophysiology of bipolar disorder was suggested. Intensive research has so far not confirmed this hypothesis, partly because lithium can also act on a number of other enzymes in this pathway, complicating results from in vitro studies.
References
Further reading
- Шаблон:Cite journal
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- Шаблон:Cite journal
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- Шаблон:Cite journal
- Шаблон:Cite journal
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- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite journal
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Inositol monophosphatase 1
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