Английская Википедия:Isochem
Шаблон:Multiple issues Шаблон:Infobox company
PMC Isochem is a French chemical company that was established in 1974 that specializes in custom chemical synthesis.
Timeline and history
- 1974: Isochem was created in Gennevilliers.
- 1977: A site was opened in Pithiviers (formerly Agrifarm), in central France.
- 1979: The company was audited and approved by the U.S. Food and Drug Administration (FDA) for the first time.
- 1990: Isochem joined the Groupe SNPE, a French holding company that specializes in explosives.
- 1991: Isochem acquired the Vert-le-Petit site (formerly IRCHA Fine Chemicals and Propeptide).[1]
- 2003: Isochem acquired the Pont-de-Claix platform and the Hungarian subsidiary Framochem.
- 2010: Isochem was acquired by the German industrial holding company Шаблон:Ill.[2]
- 2012: Isochem acquired Wychem (UK).[3],[4]
- 2014: Isochem sold its Framochem subsidiary.
- 2016: Isochem sold its Wychem subsidiary.
- 2017: PMC Group France, a wholly owned subsidiary of PMC Group International Inc., announced the acquisition of Isochem. This resulted in the name change to PMC Isochem.[5]
In its early days, Isochem mainly specialized in the extraction and semi-synthesis of natural substances, such as quinine.
In the 1990s, Isochem collaborated with Groupe SNPE (Société Nationale des Poudres et Explosifs) to implement technologies such as phosgenation,[6] nitration, and the manufacture of amino-acid derivatives such as NCAs,[7],[8] UNCAs, and peptides.[9],[10]
Now, Isochem has expanded to the field of multi-step industrial production[11] encompassing operations including Grignard, Friedel-Crafts, Sandmeyer, Vilsmeier-Haack Reaction, deprotonation using butyllithium, and reduction using metal hydrides and hydrogenation.[12]
Industrial sites and specific expertise
Isochem's industrial sites include:
- Vert-le-Petit: Head office and phosgene chemistry.
- Gennevilliers: Fractional distillation and cold reactions (-70 °C).
- Pithiviers: Hydrogenation under pressure and waste processing.[13][14]
- Pont de Claix: Active ingredients and intermediates for agrochemicals.
Most sites have a research and development team; in addition, the Vert-le-Petit site has the equipment required to study process safety.[15]
References
External links
- ↑ Infogreffe Isochem
- ↑ [1], Isochem cherche des chemins pour grandir, Industrie Pharma, octobre, 2010.
- ↑ [2], Isochem rachète la société britannique Wychem, Industrie Pharma, janvier, 2013.
- ↑ [3], Isochem renforce son offre en chimie fine et s'implante en Grande-Bretagne, Usine Nouvelle, juillet, 2013.
- ↑ Шаблон:Cite web
- ↑ Phosgene Futures, Specialty Chemicals Magazine, November, 2011.
- ↑ [4], Controlled Ring Opening of N-Sulfinyl- and N-Silyl-N-Carboxyanhydrides (NCA), Synlett, 2009 (2), 279-283.
- ↑ Amino-Acid N-CarboxyAnhydrides: Industrial solutions for a growing demand, Specialty Chemicals Magazine, 28, n°5, June, 2008.
- ↑ Peptide synthesis and Fine Chemistry merging for progress, PharmaChem, novembre-december, 2004
- ↑ UNCAs - Focus on peptides & Amino-acids, Chimica Oggi / Chemistry Today, 23, n°3, June, 2005.
- ↑ Growing challenges of API process development in custom manufacturing, Chimica Oggi / Chemistry Today, 27, n°5, september-october, 2009.
- ↑ Hydrogenation the key?, Specialty Chemicals Magazine, juin, 2009.
- ↑ La Société Isochem à la pointe du traitement des déchets, Le Courrier du Loiret, n°3439, 29 novembre 2012
- ↑ Isochem vise l'autonomie totale - Traitement des rejets, La République - Pithiviers, 29 novembre 2012.
- ↑ [5] Шаблон:Webarchive, Phosgene-triphosgene: different approach in risk management?, Chimica Oggi / Chemistry Today, 29, n°4, july-august, 2011.
