Английская Википедия:5-MeO-MiPT
Шаблон:Short description Шаблон:Drugbox
5-MeO-MiPT is a psychedelic and hallucinogenic drug, used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT. It is commonly used as a "substitute" for 5-MeO-DiPT because of the very similar structure and effects.
Chemistry
5-MeO-MiPT is in a class of compounds commonly known as tryptamines, and is the N-methyl-N-isopropyl homologue of the psychedelic, 5-MeO-DMT. The full name of the chemical is 5-methoxy-N-methyl-N-isopropyltryptamine.
5-MeO-MiPT causes the ehrlich reagent to turn purple then fade to faint blue. It causes the marquis reagent to go yellow through to black.[1]
Effects
This is an analogue of the more popular drug 5-MeO-DiPT (nicknamed "foxy methoxy") and has the nickname "moxy". Some users report the tactile effects of 5-MeO-DiPT without some of the unwanted side effects. At higher doses it becomes much more psychedelic sometimes being compared to 5-MeO-DMT. But at doses of 4-10 milligrams users find 5-MeO-MiPT to be a very euphoric and tactile chemical.[2][3] Its energetic effects can be very strong at high doses, increasing normal heart rate considerably. Sounds can be amplified in perception to a point where synesthetic effects ("touching or/and tasting sounds") occur.[4]
Pharmacodynamics
Binding Sites | Binding Affinity Ki (μM)[5] |
---|---|
5-HT1A | 0.058 |
5-HT2A | 0.163 |
5-HT2C | 1.3 |
D1 | >25 |
D2 | >25 |
D3 | >25 |
α1A | >12 |
α2A | 5.3 |
TAAR1 | >15 |
H1 | 3.9 |
SERT | 3.3 |
DAT | >26 |
NET | >22 |
Dosage
Based on many anecdotal reports,[6][7] dosages can be classified as follows:
Smoked | Oral | |
---|---|---|
Threshold | 5 mg | 3 mg |
Light | 5 - 10 mg | 3 - 7 mg |
Common | 10 - 15 mg | 7 - 15 mg |
Strong | 15 - 20 mg | 15 - 20 mg |
Heavy | 20 mg + | 20 mg + |
Pharmacology
The mechanism that produces the hallucinogenic and entheogenic effects of 5-MeO-MiPT is thought to result primarily from 5-HT2A receptor agonism, although additional mechanisms of action such as inhibition of MAO may be involved also.[8][9] While 5-MeO-MiPT binds most strongly to 5-HT1A receptors, it also shows fairly strong binding affinity to the SERT and NET, thereby acting as a moderately potent serotonin-norepinephrine reuptake inhibitor.[10] These mechanisms may help explain why there are many anecdotal reports of anti-depressant and anxiolytic effects from modest doses of this compound. For example, SNRIs such as venlafaxine are commonly prescribed to treat depression, and the 5-HT1A agonist buspirone is prescribed primarily for treatment of anxiety.
Reagent Results
Exposing compounds to the reagents gives a colour change which is indicative of the compound under test. The following test results are from protestkit.
5-MeO-MiPT | Marquis | Mecke | Mandelin | Liebermann | Ehrlich | Hofmann | Simon’s |
---|---|---|---|---|---|---|---|
Freebase | Orange to brown | Orange red | Deep greenish brown | Unknown | Purple | No reaction | No reaction |
HCl | Orange to brown | Red to brown | Greenish brown | Brown | Violet to purple | Green | Unknown |
Dangers
The toxicity of 5-MeO-MiPT is not known. There is no known documentation of death attributed to the use of 5-MeO-MiPT alone.
Legal status
Canada
5-MeO-MiPT is not scheduled in Canada.Шаблон:Citation needed
China
As of October 2015 5-MeO-MiPT is a controlled substance in China.[11]
Finland
Scheduled in government decree on psychoactive substances banned from the consumer market.[12]
Luxembourg
In Luxembourg, 5-MeO-MiPT is not cited in the list of prohibited substances.[13] Therefore, it is still a legal substance.
United Kingdom
5-MeO-MiPT is a Class A drug in the United Kingdom as are most ethers of ring-hydroxy tryptamines.Шаблон:Citation needed
United States
5-MeO-MiPT is unscheduled at the federal level in the United States,[14] but it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession with intent to consume could be prosecuted under the Federal Analog Act.
Florida
"5-Methoxy-N-methyl-N-isopropyltryptamine" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in the state of Florida.[15]
See also
References
External links
Шаблон:Entactogens Шаблон:Hallucinogens Шаблон:Tryptamines