Английская Википедия:ADAM 17 endopeptidase

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Шаблон:Short description Шаблон:Infobox enzyme ADAM 17 endopeptidase (Шаблон:EC number, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains

This enzyme belongs to the peptidase family M12.

References

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External links

Шаблон:Metalloendopeptidases Шаблон:Enzymes Шаблон:Portal bar