Английская Википедия:Adrenergic urticaria

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Шаблон:Infobox medical condition (new) Adrenergic urticaria is a skin condition characterized by an eruption consisting of small (1-5mm) red macules and papules with a pale halo, appearing within 10 to 15 min after emotional upset.[1]Шаблон:Rp[2] There have been 10 cases described in medical literature, and involve a trigger (coffee, intense emotions) followed by a rise in catecholamine and IgE. Treatment involves propranolol and trigger avoidance.[3]

Mechanism

The underlying mechanisms are not fully understood, but existing research suggests that adrenergic urticaria is linked with elevated serum catecholamine levels. The characteristic halo hives are most likely caused by catecholamine-induced peripheral vasoconstriction around erythematous wheals, which is consistent with other types of urticaria.[3]

Diagnosis

The diagnosis of AU can be made either clinically or by giving an intradermal injection of adrenaline or noradrenaline, which causes the rash, or by monitoring the body's reaction to propranolol, which suppresses the rash and prevents further exacerbations.[4] Skin biopsy specimens of adrenergic urticaria show edematous tissues with a vague inflammatory infiltrate, and electron microscopy reveals mast cell degranulation, supporting the currently accepted theory that mast cells regulate pathogenesis.[3]

See also

References

Шаблон:Reflist

  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Шаблон:ISBN.
  2. Шаблон:Cite book
  3. 3,0 3,1 3,2 Шаблон:Cite journal
  4. Шаблон:Cite journal