Английская Википедия:CYP11 family

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Шаблон:Short description Шаблон:Cs1 config

Файл:CYP Gene Superfamily.png
The evolutionary divergence of the CYP superfamily collected in 1990, CYP11, CYP10 and CYP27 are in the same branch,[1] which is now called Mitochondrial clan CYPs.[2]

Cytochrome P450, family 11, also known as CYP11, is a chordate cytochrome P450 monooxygenase family. This family contains many enzymes involved in steroidogenesis, such as Cholesterol side-chain cleavage enzyme (CYP11A1), Steroid 11β-hydroxylase (CYP11B1) and Aldosterone synthase (CYP11B2).[3] CYP11 can be divided into A to E five subfamilies,[4] and CYP11A are the ohonologues to CYP11C, which duplicated during 2R event, and the tetrapod's CYP11B evolved from CYP11C of its fish ancestors,[2] CYP11D and F found in amphioxus.[4] These are not the typical CYP subfamilies, which share at least 40% amino acid identity,[5] members between CYP11A and B subfamily are only 37.5-38.8% identical,[6] and the CYP11D and E genes seen in modern lancelet (Branchiostoma floridae, an ancient branch of chordate animals) is 39% identical to catfish CYP11A1.[2][4]

References

Шаблон:Reflist Шаблон:Cytochrome P450


Шаблон:Genetics-stub