Английская Википедия:Caroxazone

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Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed.[1][2] It acts as a reversible monoamine oxidase inhibitor (RIMA) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.[3][4][5][6][7]

Synthesis

Файл:Caroxazone synthesis.svg
Caroxazone synthesis:[8][9][10][11][12]

Synthesis starts by reductive amination of salicylaldehyde and glycinamide to give 3. The synthesis is completed by reaction with phosgene and NaHCO3.

See also

References

Шаблон:Reflist

Шаблон:Antidepressants Шаблон:Anxiolytics Шаблон:Monoamine metabolism modulators