Английская Википедия:Chromosome 16
Шаблон:Short description Шаблон:Infobox chromosome Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 96 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells.
Genes
Number of genes
The following are some of the gene count estimates of human chromosome 16. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[1]
| Estimated by | Protein-coding genes | Non-coding RNA genes | Pseudogenes | Source | Release date |
|---|---|---|---|---|---|
| CCDS | 795 | — | — | [2] | 2016-09-08 |
| HGNC | 802 | 251 | 365 | [3] | 2017-05-12 |
| Ensembl | 865 | 1,046 | 462 | [4] | 2017-03-29 |
| UniProt | 838 | — | — | [5] | 2018-02-28 |
| NCBI | 912 | 652 | 502 | [6][7][8] | 2017-05-19 |
Gene list
Шаблон:Category see also The following is a partial list of genes on human chromosome 16. For complete list, see the link in the infobox on the right. Шаблон:Columns-list
Diseases and disorders
- Attention deficit hyperactivity disorder (ADHD)
- Asperger syndrome
- Autism spectrum disorder[9][10]
- Autosomal dominant polycystic kidney disease (PKD-1)
- Batten disease
- Combined malonic and methylmalonic aciduria (CMAMMA)
- Familial Mediterranean fever (FMF)
- Synesthesia
- Thalassemia
- Trisomy 16
- Morquio syndrome
Associated traits
Cytogenetic band
| Chr. | Arm[12] | Band[13] | ISCN start[14] |
ISCN stop[14] |
Basepair start |
Basepair stop |
Stain[15] | Density |
|---|---|---|---|---|---|---|---|---|
| 16 | p | 13.3 | 0 | 352 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | p | 13.2 | 352 | 596 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | p | 13.13 | 596 | 813 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | p | 13.12 | 813 | 948 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | p | 13.11 | 948 | 1070 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | p | 12.3 | 1070 | 1246 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | p | 12.2 | 1246 | 1409 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | p | 12.1 | 1409 | 1558 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | p | 11.2 | 1558 | 1856 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | p | 11.1 | 1856 | 2045 | Шаблон:Val | Шаблон:Val | acen | |
| 16 | q | 11.1 | 2045 | 2194 | Шаблон:Val | Шаблон:Val | acen | |
| 16 | q | 11.2 | 2194 | 2709 | Шаблон:Val | Шаблон:Val | gvar | |
| 16 | q | 12.1 | 2709 | 2953 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 12.2 | 2953 | 3142 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | q | 13 | 3142 | 3346 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 21 | 3346 | 3657 | Шаблон:Val | Шаблон:Val | gpos | 100 |
| 16 | q | 22.1 | 3657 | 4023 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 22.2 | 4023 | 4118 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | q | 22.3 | 4118 | 4294 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 23.1 | 4294 | 4551 | Шаблон:Val | Шаблон:Val | gpos | 75 |
| 16 | q | 23.2 | 4551 | 4659 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 23.3 | 4659 | 4768 | Шаблон:Val | Шаблон:Val | gpos | 50 |
| 16 | q | 24.1 | 4768 | 4930 | Шаблон:Val | Шаблон:Val | gneg | |
| 16 | q | 24.2 | 4930 | 5025 | Шаблон:Val | Шаблон:Val | gpos | 25 |
| 16 | q | 24.3 | 5025 | 5120 | Шаблон:Val | Шаблон:Val | gneg |
References
Шаблон:Reflist Шаблон:Refbegin
- Шаблон:Cite journal
- Шаблон:Cite journal
- Шаблон:Cite book In Шаблон:Cite book
- http://omim.org/search?index=geneMap&search=16p13.3
External links
Шаблон:Chromosomes Шаблон:Chromosome genetics
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
- ↑ "p": Short arm; "q": Long arm.
- ↑ For cytogenetic banding nomenclature, see article locus.
- ↑ 14,0 14,1 These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
- ↑ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
