Английская Википедия:DUSP16

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[1][2][3][4]

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][4]

Interactions

DUSP16 has been shown to interact with MAPK14[5][6] and MAPK8IP1.[7]

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16


Шаблон:Protein tyrosine phosphatases


Шаблон:Gene-12-stub